HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentabromide → 1-(2-Bromoethyl)adamantane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentabromide | HCID 62678 | — |
| Reactant | 2-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanol | HCID 110810 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(2-Bromoethyl)adamantane | HCID 1416305 | — |
Reaction Steps
1-Hydroxy-2-(adamant-1-yl)ethane (901.0 mg, 5.0 mmol) was treated with phosphorus pentabromide(3.0 gm, 7.0 mmol) in diethyl ether and warmed slightly until a noticeable exotherm was observed. The resulting red solution was washed with aqueous sodium bicarbonate solution and dried (Na2SO4). Solvent removal gave crude 1-Bromo-2-(adamant-1-yl)ethane. The material was used as is without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06335343B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-d263aac3371748c98cb03507153df8b8 |
| Source note | uspto-grants-2002_01 |