反应详情

A soution of (4-nitro-2,6-dichloro-phenoxy)-acetic acid tert-butyl ester (1 g) in ethanol (17 mL) and water (8.6 mL) is treated with iron powder (0.861 g) and ammonium chloride (86 mg) and the mixture is heated to reflux for approximately 1 hour. The mixture is then filtered and concentrated under reduced pressure. The resulting oil is partitioned between water and ethyl acetate, and the organic phase is then washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to provide the desired compound as a pale yellow solid.

1. temperaturethe mixture is heated
2. temperatureto reflux for approximately 1 hour
3. filtrationThe mixture is then filtered
4. concentrationconcentrated under reduced pressure
5. customThe resulting oil is partitioned between water and ethyl acetate
6. washthe organic phase is then washed with saturated aqueous sodium chloride
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated under reduced pressure