Propylene Glycol → L-lactide epsilon-caprolactone

HRID 1249910Notes

Reaction equation

HRID 1249910 reaction equation
[CH2:1]([OH:5])[CH:2]([OH:4])[CH3:3]>C(O)(C(F)(F)F)C(F)(F)F>[C:1]1(=[O:5])[O:5][CH2:1][CH2:2][CH2:3][CH2:3][CH2:2]1.[CH3:3][C@@H:2]1[O:4][C:1](=[O:5])[C@H:2]([CH3:3])[O:4][C:1]1=[O:5]

Participants

3

Reactant 1

HCID 1030Propylene Glycol

Product 1

HCID 131710947L-lactide epsilon-caprolactone

Reagents, catalysts & solvents 1

HCID 135291,1,1,3,3,3-Hexafluoro-2-propanolSolvent

Procedure

The procedure in Example 3 was substantially repeated, except that 4.4 mL (60 mmol) propylene glycol (USP grade) was used instead of 5.6 mL of 1-dodecanol. The copolymer had an inherent viscosity of 0.17 dL/g in HFIP at 25° C.

Workup

  1. customat 25° C.

Sources & evidence

ORD record
ord-87ea280ad50d4b1587b21ad9997b7792
Source dataset
uspto-grants-2002_01
Patent number
US06335383B1

Reaction notes

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