Ethyl 5-chloroindole-2-carboxylate → HCID 22451271, compound

HRID 1249943Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([O:13][CH2:14]C)=[O:12])=[CH:5]2.[Mg]>>[CH3:14][O:13][C:11]([CH:6]1[CH2:5][C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=2)[NH:7]1)=[O:12]

Participants

Reactant 2

HCID 78518Ethyl 5-chloroindole-2-carboxylate

HCID 5462224Magnesium2×

Product 1

HCID 22451271HCID 22451271, compound

Procedure

This compound was prepared from ethyl 5-chloroindole-2-carboxylate as described in example 1. However this time 5-6 equivalence of magnesium turnings were used instead of 2-3 eq. of magnesium turnings.

Sources & evidence

ORD record: ord-20455f26de584160bbe8308e2d7152df
Source dataset: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06335360B1

Reaction notes

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