Potassium Carbonate → HCID 131723080, compound

HRID 1249949Notes

Reaction equation

HRID 1249949 reaction equation
[F:1][C:2]([F:36])([F:35])[CH2:3][NH:4][C:5]([CH:7]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:16]#[C:17][Si](C)(C)C)[CH:13]=2)[N:8]1[C:22](=[O:34])[C@@H:23]([NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:24][CH3:25])=[O:6].C(=O)([O-])[O-].[K+].[K+]>CO>[F:36][C:2]([F:1])([F:35])[CH2:3][NH:4][C:5]([CH:7]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:16]#[CH:17])[CH:13]=2)[N:8]1[C:22](=[O:34])[C@@H:23]([NH:26][C:27]([O:29][C:30]([CH3:31])([CH3:33])[CH3:32])=[O:28])[CH2:24][CH3:25])=[O:6]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 131723081HCID 131723081, compound

Product 1

HCID 131723080HCID 131723080, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the solution of 1-[N-t-butoxycarbonyl-2(S)-aminobutyryl]-5-(trimethylsilyl)ethynylindoline-2(R/S)-carboxylic acid (2,2,2-trifluoroethyl)amide (0.43 g, 0.81 mmol) in anhydrous methanol (7ml), potassium carbonate (0.02 g) was added under an atmosphere of nitrogen and stirred at room temperature for several hours. The solvent was evaporated in vacuo.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-39819160dbc240578bb463b268793018
Source dataset
uspto-grants-2002_01
Patent number
US06335360B1

Reaction notes

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