Iodoethane → 1-Ethyl-1,4-diazepane

HRID 1249978Notes

Reaction equation

HRID 1249978 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:8](I)[CH3:9]>C(O)C>[CH2:8]([N:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH3:9]

Participants

4

Reactant 2

HCID 6340IodoethaneHCID 68163Hexahydro-1,4-diazepine

Product 1

HCID 75775381-Ethyl-1,4-diazepane

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Homopiperazine (100 g) is dissolved in ethanol (500 ml), and thereto is added dropwise gradually ethyl iodide (19.8 ml). The mixture is stirred at room temperature overnight, and the insoluble materials are removed by filtration. The filtrate is evaporated to remove the solvent. Purification is perfomed by distillation to give 1-ethylhomopiperazine (50 g) as colorless oil.

Workup

  1. customthe insoluble materials are removed by filtration
  2. customThe filtrate is evaporated
  3. customto remove the solvent
  4. customPurification
  5. distillationis perfomed by distillation

Sources & evidence

ORD record
ord-3f3d11d0cd034940bc1799d76a5ed13c
Source dataset
uspto-grants-2002_01
Patent number
US06335327B1

Reaction notes

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