Hydrochloric Acid → 4'-(4-Chloro-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfonamide

HRID 1250046Notes

Reaction equation

HRID 1250046 reaction equation
CN(C=[N:5][S:6]([C:9]1[C:10]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:22]3[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:17][CH:16]=2)=[CH:11][CH:12]=[CH:13][CH:14]=1)(=[O:8])=[O:7])C.Cl>C(O)C>[Cl:29][C:25]1[N:24]=[C:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[N:22]([CH2:21][C:18]2[CH:17]=[CH:16][C:15]([C:10]3[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:20][CH:19]=2)[C:26]=1[CH:27]=[O:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 867577064'-(4-Chloro-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfonic acid dimethylaminomethylenamide

Product 1

HCID 184000704'-(4-Chloro-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfonamideYield 100.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.9 g of 4′-(4-chloro-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfonic acid dimethylaminomethylenamide were dissolved in 20 ml of ethanol and 20 ml of a saturated aqueous HCl solution were added. The mixture was heated under reflux for 2 hours, then the volatile constituents were removed in vacuo, the residue was taken up using 200 ml of water, the solution was adjusted to pH-7 using aqueous NaOH solution and stirred for 1 hour, and the precipitate was filtered off with suction. The product was dried in vacuo, and 1.7 g of a colorless solid were obtained,

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 2 hours
  3. customthe volatile constituents were removed in vacuo
  4. filtrationthe precipitate was filtered off with suction
  5. customThe product was dried in vacuo

Sources & evidence

ORD record
ord-f24490f4e4884cabaee7a7d4dbcaa6be
Source dataset
uspto-grants-2002_01
Patent number
US06335451B1

Reaction notes

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