Methanol → 4'-(4-Methoxy-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfon-amide

HRID 1250047Notes

Reaction equation

HRID 1250047 reaction equation
Cl[C:2]1[N:3]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([S:22]([NH2:25])(=[O:24])=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:6]=1[CH:7]=[O:8].[OH-:32].[Na+].[CH3:34]O>>[CH3:34][O:32][C:2]1[N:3]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([S:22]([NH2:25])(=[O:24])=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:6]=1[CH:7]=[O:8]

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 184000704'-(4-Chloro-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfonamide

Product 1

HCID 184000924'-(4-Methoxy-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfon-amide

Procedure

700 mg of 4′-(4-chloro-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfonamide (Example 11b) and 620 mg of NaOH were dissolved in 10 ml of methanol and heated under reflux for 1 hour. The solvent was removed in vacuo, the residue was taken up with 20 ml of water, the solution was adjusted to pH=7 using aqueous HCl solution and the precipitate was filtered off. It was dried in vacuo, and 650 mg of a colorless solid were obtained,

Workup

  1. temperatureheated
  2. temperatureunder reflux for 1 hour
  3. customThe solvent was removed in vacuo
  4. filtrationthe precipitate was filtered off
  5. customIt was dried in vacuo

Sources & evidence

ORD record
ord-4a8ae395059a4ae3bfe946bf1dc712ae
Source dataset
uspto-grants-2002_01
Patent number
US06335451B1

Reaction notes

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