Methanol → 4'-(4-Methoxy-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfon-amide

Participants

Reaction Steps

700 mg of 4′-(4-chloro-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfonamide (Example 11b) and 620 mg of NaOH were dissolved in 10 ml of methanol and heated under reflux for 1 hour. The solvent was removed in vacuo, the residue was taken up with 20 ml of water, the solution was adjusted to pH=7 using aqueous HCl solution and the precipitate was filtered off. It was dried in vacuo, and 650 mg of a colorless solid were obtained,

Provenance & Evidence