3-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indole → 4-(6-Fluoro-1H-indol-3-YL)cyclohexanone

HRID 1250157Notes

Reaction equation

HRID 1250157 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]3[C:19]4[C:14](=[CH:15][C:16]([F:20])=[CH:17][CH:18]=4)[NH:13][CH:12]=3)[CH2:7][CH2:6]2)[O:4]CC1.O1C2(CCC(C3C4C(=CC=CC=4)NC=3)CC2)OCC1>>[F:20][C:16]1[CH:15]=[C:14]2[C:19]([C:11]([CH:8]3[CH2:7][CH2:6][C:5](=[O:4])[CH2:10][CH2:9]3)=[CH:12][NH:13]2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 108487533-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indoleHCID 184140863-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole

Product 1

HCID 154812814-(6-Fluoro-1H-indol-3-YL)cyclohexanoneYield 60%

Procedure

The title compound was prepared according to the procedure of Example 1, Step 3 except that 3-(1,4-dioxa-spiro[4.5]dec-8-yl)-6-fluoro-1H-indole was used instead 3-(1,4-Dioxa-spiro[4.5]dec-8-yl)-1H-indole. Yield: 60%; MS (ES) m/z (relative intensity): 429 (M++H, 100).

Sources & evidence

ORD record
ord-e627997d3ded41178a95ab0b34d93b17
Source dataset
uspto-grants-2002_01
Patent number
US06337326B1

Reaction notes

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