Dichloromethane → HCID 9949224, compound

HRID 1250183Notes

Reaction equation

HRID 1250183 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([NH2:11])=[CH:3][CH:2]=1.[N-:12]=[C:13]=[O:14].[Cl:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=1[CH3:22].[CH2:23](Cl)Cl>>[Cl:15][C:16]1[CH:17]=[C:18]([NH:12][C:13]([NH:11][C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=[C:2]([CH3:23])[CH:3]=2)=[O:14])[CH:19]=[CH:20][C:21]=1[CH3:22]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 684764-AminoquinolineHCID 86757710HCID 86757710, compound

Product 1

HCID 9949224HCID 9949224, compound

Procedure

To a solution of 4-quinolinylamine (1 mmol) in CH2Cl2 at room temperature was added slowly 3-Chloro-4-methylbenzenisocyanate (1.1 mmol). The reaction was allowed to stir for 2 h, and precipitation occurred. The reaction mixture was filtered and a white solid collected. This was recrystallized from hexane/EtOAc to afford white crystals.

Workup

  1. customprecipitation
  2. filtrationThe reaction mixture was filtered
  3. customa white solid collected
  4. customThis was recrystallized from hexane/EtOAc
  5. customto afford white crystals

Sources & evidence

ORD record
ord-b7f136f283f945808cfe8af7a61deea4
Source dataset
uspto-grants-2002_01
Patent number
US06337338B1

Reaction notes

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