反应详情

Dissolved methyl 3-(3,3-dimethyl-2-oxopentanoyl)-1,3-oxazolidine-4-carboxylate (3) (0.6 g, 2.33 mM) in MeOH (25 ml) and added LiOH (1M in water, 10 ml, 10 mM). Stirred this mixture overnight at room temperature. Evaporated and partitioned the residues between EtOAc (50 ml) and 2N HCl (50 mL). Extracted the aqueous layer twice more with EtOAc (2×25 ml). Combined extracts, washed with brine (50 ml), dried with anhydrous magnesium sulfate, filtered and evaporated. A clear oil product (0.49 g, 86%) was obtained. Anal. (C11H17NO5) C, H, N.

1. customEvaporated
2. custompartitioned the residues between EtOAc (50 ml) and 2N HCl (50 mL)
3. extractionExtracted the aqueous layer twice more with EtOAc (2×25 ml)
4. washCombined extracts, washed with brine (50 ml)
5. dry with materialdried with anhydrous magnesium sulfate
6. filtrationfiltered
7. customevaporated