HCID 70167036, compound → HCID 70165935, compound

HRID 1250234Notes

Reaction equation

HRID 1250234 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]2[N:19]([CH2:20][CH2:21][CH2:22][CH:23]3[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[CH2:25][CH2:24]3)[C:18](=[O:37])[C:17]3[C:12](=[C:13]([O:38]C)[CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[CH:4][CH:3]=1>Br.CC(O)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]2[N:19]([CH2:20][CH2:21][CH2:22][CH:23]3[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:25][CH2:24]3)[C:18](=[O:37])[C:17]3[C:12](=[C:13]([OH:38])[CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 70167036HCID 70167036, compound

Product 1

HCID 70165935HCID 70165935, compound

Reagents, catalysts & solvents 1

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidSolvent

Procedure

A solution of 2-[2-(4-chloro-phenyl)-vinyl]-8-methoxy-3-[3-(1-phenethyl-piperidin-4-yl)-propyl]-3H-quinazolin-4-one (530 mg, 0.98 mmol) in conc HBr/HOAc (1:1 mixture, 60 mL) was heated at 120° C. for 48 h. After cooling to room temperature, the reaction mixture was concentrated under vacuum to yield the desired product. API-MS: 529 (M+1)

Workup

  1. concentrationthe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-a7c47d77535743dd990cb61082bb41c6
Source dataset
uspto-grants-2002_01
Patent number
US06337332B1

Reaction notes

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