1,4-Dibromobutane → HCID 18328044, compound

HRID 1250298Notes

Reaction equation

HRID 1250298 reaction equation
[CH3:1][C:2]1[NH:8][C:7](=[O:9])[C:6]2[CH:10]=[C:11]([CH3:14])[CH:12]=[CH:13][C:5]=2[O:4][CH:3]=1.[Br:15][CH2:16][CH2:17][CH2:18][CH2:19]Br.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:15][CH2:16][CH2:17][CH2:18][CH2:19][N:8]1[C:7](=[O:9])[C:6]2[CH:10]=[C:11]([CH3:14])[CH:12]=[CH:13][C:5]=2[O:4][CH:3]=[C:2]1[CH3:1]

Participants

5

Reactant 3

HCID 80561,4-DibromobutaneHCID 11430Potassium CarbonateHCID 18328155HCID 18328155, compound

Product 1

HCID 18328044HCID 18328044, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

950 mg of 4,5-dihydro-3,7-dimethyl-1,4-benzoxazepin-5-one was dissolved in 30 ml of acetone, 4.3 g (4 equivalents) of 1,4-dibromobutane and 2.1 g (3 equivalents) of potassium carbonate were added, then the resultant mixture was heated and refluxed for 10 hours.

Workup

  1. temperaturerefluxed for 10 hours

Sources & evidence

ORD record
ord-6336dc243f86414d9b345cd134e0c381
Source dataset
uspto-grants-2002_01
Patent number
US06337397B1

Reaction notes

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