HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(Piperidin-4-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-(pyrimidin-2-yl)piperidine-1-carboxylate | HCID 18328041 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Piperidin-4-yl)pyrimidine | HCID 15516969 | — |
Reaction Steps
1.5 g of the compound of step 1 of Example 26 was dissolved in 30 ml of methylene chloride, 10 ml of TFA was added, then the resultant mixture was agitated at room temperature for 30 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06337397B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-c5f9ad5283964d5cabe81b81a84055e9 |
| Source note | uspto-grants-2002_01 |