Trifluoroacetic acid → 2-(Piperidin-4-yl)pyrimidine

HRID 1250306Notes

Reaction equation

HRID 1250306 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:15]1[CH:16]=[CH:17][CH:18]=[N:19][C:14]=1[CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18328041tert-Butyl 4-(pyrimidin-2-yl)piperidine-1-carboxylate

Product 1

HCID 155169692-(Piperidin-4-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 g of the compound of step 1 of Example 26 was dissolved in 30 ml of methylene chloride, 10 ml of TFA was added, then the resultant mixture was agitated at room temperature for 30 minutes.

Sources & evidence

ORD record
ord-c5f9ad5283964d5cabe81b81a84055e9
Source dataset
uspto-grants-2002_01
Patent number
US06337397B1

Reaction notes

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