Ammonia → Octyl 4'-hydroxy-4-biphenylcarboxylate

HRID 1250328Notes

Reaction equation

HRID 1250328 reaction equation
COC([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)=O.N.ClCCl>C(O)C>[OH:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[O:19])=[CH:14][CH:13]=2)=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 6344DichloromethaneHCID 18328376Octyl4'-methoxycarbonyloxy-4-biphenylcarboxylate

Product 1

HCID 14692993Octyl 4'-hydroxy-4-biphenylcarboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of compound 5 (5.25 g, 0.014 mol) and aqueous ammonia (35% w/v, 100 ml) in ethanol (200 ml) was stirred for 1 h at room temperature. TLC analysis (dichloromethane) revealed a complete reaction. The solvent was removed in vacuo and the white solid was recrystallised from ethanol to give colourless crystals.

Workup

  1. customa complete reaction
  2. customThe solvent was removed in vacuo
  3. customthe white solid was recrystallised from ethanol
  4. customto give colourless crystals

Sources & evidence

ORD record
ord-c4487588a82e4d27b7e1d34260227de1
Source dataset
uspto-grants-2002_01
Patent number
US06337420B1

Reaction notes

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