HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzonitrile, 3-(bromomethyl)- → 4-methyl-1H-indole-2-carboxylic acid 3-cyano-benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzonitrile, 3-(bromomethyl)- | HCID 97249 | — |
| Reactant | 4-Methyl-1H-indole-2-carboxylic acid | HCID 3926087 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-methyl-1H-indole-2-carboxylic acid 3-cyano-benzyl ester | HCID 54172561 | 75% |
Reaction Steps
The starting material was 4-methyl-1H-indole-2-carboxylic acid. Alkylation with 3-cyano-benzylbromide (analogously to example 19/1, but the solvent was dimethylformamide instead of tetrahydrofuran) gave 4-methyl-1H-indole-2-carboxylic acid 3-cyano-benzyl ester. Yield: 75%. MS: 291.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06337344B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-8868bb227729428eaf0f9d2d4cf383d6 |
| Source note | uspto-grants-2002_01 |