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HRID1250396

反应详情

EQUATION

反应方程式

HRID 1250396 的结构方程式

REACTANTS

反应物

2
结构：N#Cc1cccc(CBr)c1
HCID97249

Benzonitrile, 3-(bromomethyl)-

C8H6BrN

结构：Cc1cccc2[nH]c(C(=O)O)cc12
HCID3926087

4-Methyl-1H-indole-2-carboxylic acid

C10H9NO2

PRODUCTS

生成物

1
结构：Cc1cccc2[nH]c(C(=O)OCc3cccc(C#N)c3)cc12
HCID54172561

未命名化合物

收率 75%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The starting material was 4-methyl-1H-indole-2-carboxylic acid. Alkylation with 3-cyano-benzylbromide (analogously to example 19/1, but the solvent was dimethylformamide instead of tetrahydrofuran) gave 4-methyl-1H-indole-2-carboxylic acid 3-cyano-benzyl ester. Yield: 75%. MS: 291.1 (M+H+).