Hydrochloric Acid → HCID 178488321, compound

HRID 1250398Notes

Reaction equation

HRID 1250398 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH:9][C:10]([C:12]2[N:13]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30](=[NH:33])[NH:31][OH:32])[CH:25]=3)[C:14]3[C:19]([CH:20]=2)=[C:18]([O:21][CH3:22])[CH:17]=[CH:16][CH:15]=3)=[O:11])=[CH:3][CH:2]=1.[ClH:34]>>[ClH:34].[ClH:34].[N:1]1[CH:2]=[CH:3][C:4]([CH2:7][CH2:8][NH:9][C:10]([C:12]2[N:13]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30](=[NH:33])[NH:31][OH:32])[CH:25]=3)[C:14]3[C:19]([CH:20]=2)=[C:18]([O:21][CH3:22])[CH:17]=[CH:16][CH:15]=3)=[O:11])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178488320HCID 178488320, compound

Product 1

HCID 178488321HCID 178488321, compoundYield 66%

Procedure

The starting material, 1-(3-hydroxyamidino-benzyl)-4-methoxy-1H-indole-2-carboxylic acid 2-(4-pyridyl)-ethyl amide (example 49), was dissolved in 0.1 N hydrochloric acid, concentrated in vacuo, dissolved in water again and lyophilized. Yield: 66%. M.p. 215-217° C. MS: 444.3 (M+H+).

Workup

  1. concentrationconcentrated in vacuo
  2. dissolutiondissolved in water again

Sources & evidence

ORD record
ord-cbda069db7d140ddb30be476ec7e4ad8
Source dataset
uspto-grants-2002_01
Patent number
US06337344B1

Reaction notes

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