Chlorosulfonic acid → HCID 15480187, compound

HRID 1250462Notes

Reaction equation

HRID 1250462 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[S:20]([OH:23])(=[O:22])=[O:21]>C(Cl)(Cl)Cl>[N:14]1([C:11]2[CH:12]=[CH:13][C:8]([O:1][C:2]3[CH:3]=[CH:4][C:5]([S:20]([OH:23])(=[O:22])=[O:21])=[CH:6][CH:7]=3)=[CH:9][CH:10]=2)[CH:18]=[CH:17][N:16]=[CH:15]1

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 183266381-(4-Phenoxyphenyl)-1H-imidazole

Product 1

HCID 15480187HCID 15480187, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

137 mmol of 1-(4-phenoxyphenyl)imidazole are dissolved in 250 ml of chloroform. 190 mmol of chlorosulphonic acid are then added dropwise. The whole is left at 45° C. overnight. After cooling and removal of the solvent by evaporation, the resulting oil is taken up in diethyl ether. The resulting solid is filtered off and dried to yield the expected product.

Workup

  1. temperatureAfter cooling
  2. customremoval of the solvent
  3. customby evaporation
  4. filtrationThe resulting solid is filtered off
  5. customdried

Sources & evidence

ORD record
ord-fabf148c68754a6dbcbf2d6965c22220
Source dataset
uspto-grants-2002_01
Patent number
US06339092B1

Reaction notes

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