Methanol → HCID 15906608, compound

HRID 1250496Notes

Reaction equation

HRID 1250496 reaction equation
[CH:1]([NH:4][C:5]([C:7]1[CH:12]=[C:11]([N:13](C)[CH2:14]C2C=CC=CC=2)[CH:10]=[C:9]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)[N:8]=1)=[O:6])([CH3:3])[CH3:2].CO.[H][H]>[Pd].C(O)(=O)C>[CH:1]([NH:4][C:5]([C:7]1[CH:12]=[C:11]([NH:13][CH3:14])[CH:10]=[C:9]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:30])[F:31])[CH:24]=2)[N:8]=1)=[O:6])([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 887MethanolHCID 18326223HCID 18326223, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15906608HCID 15906608, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

1.12 g (0.0012 mol) of N-(i-propyl)-4-(methyl(phenylmethyl)amino}-6-{3-(trifluoromethyl)phenoxy}-2-pyridine carboxamide were mixed with methanol and then with a small amount of 10% palladium/carbon and acetic acid. The obtained mixture was stirred at room temperature for about 16 hours in a hydrogen atmosphere. The obtained reaction solution was filtered using Hyflo Super Cell and then concentrated. The concentrate was purified by silica gel column chromatography (eluting solution: ethyl acetate/hexane), thereby obtaining an aimed product.

Workup

  1. customThe obtained reaction solution
  2. filtrationwas filtered
  3. concentrationconcentrated
  4. customThe concentrate was purified by silica gel column chromatography (eluting solution: ethyl acetate/hexane)

Sources & evidence

ORD record
ord-524a3be675184c3c9a637c7d8e338cee
Source dataset
uspto-grants-2002_01
Patent number
US06339045B1

Reaction notes

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