Methanol → HCID 15906608, compound

Participants

Reaction Steps

1.12 g (0.0012 mol) of N-(i-propyl)-4-(methyl(phenylmethyl)amino}-6-{3-(trifluoromethyl)phenoxy}-2-pyridine carboxamide were mixed with methanol and then with a small amount of 10% palladium/carbon and acetic acid. The obtained mixture was stirred at room temperature for about 16 hours in a hydrogen atmosphere. The obtained reaction solution was filtered using Hyflo Super Cell and then concentrated. The concentrate was purified by silica gel column chromatography (eluting solution: ethyl acetate/hexane), thereby obtaining an aimed product.

Provenance & Evidence