Methylamine → HCID 18326456, compound

HRID 1250568Notes

Reaction equation

HRID 1250568 reaction equation
[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7](Cl)[N:6]=1)[CH:2]=[CH2:3].[CH3:19][NH2:20]>O>[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7]([NH:20][CH3:19])[N:6]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 183264874-Allylamino-2-chloro-6-nitroquinazoline

Product 1

HCID 18326456HCID 18326456, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 230 mg (0.87 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline and 902 mg (12.88 mmol) of a 40% aqueous methylamine solution was stirred at room temperature for 30 minutes. Water was added to the reaction mixture, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 190 mg (yield: 84.2%) of the title compound.

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing with brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by a silica gel column

Sources & evidence

ORD record
ord-edb1247d07224ba3a1ff618ffeb80d96
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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