Isopropylamine → HCID 18326565, compound

HRID 1250570Notes

Reaction equation

HRID 1250570 reaction equation
[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7](Cl)[N:6]=1)[CH:2]=[CH2:3].[CH:19]([NH2:22])([CH3:21])[CH3:20]>O>[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7]([NH:22][CH:19]([CH3:21])[CH3:20])[N:6]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 183264874-Allylamino-2-chloro-6-nitroquinazoline

Product 1

HCID 18326565HCID 18326565, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 250 mg (0.95 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline and 694 mg (11.74 mmol) of isopropylamine was stirred at room temperature for 3 hours. Water was added to the reaction mixture, and crystals thus precipitated were filtered to give 270 mg (yield: 99.4%) of the title compound.

Workup

  1. customthus precipitated
  2. filtrationwere filtered

Sources & evidence

ORD record
ord-bdcb88a2e8f64ef3857dde83a8e68125
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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