反应详情

To 170 mg (0.61 mmol) of 2-chloro-6-nitro-4-pentylaminoquinazoline was added 1.52 g (26.66 mmol) of allylamine, followed by stirring at room temperature overnight. To the reaction solution was water added, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 160 mg (yield: 83.6%) of a free base compound of the title compound.

1. additionadded
2. extractionfollowed by extraction with ethyl acetate
3. washwashing with brine
4. dry with materialdrying over anhydrous sodium sulfate
5. distillationAfter the solvent was distilled off
6. customthe residue was purified by a silica gel column