反应详情

温度

150 °C

To 5 ml of a solution of 123 mg (0.50 mmol) of 2-allylamino-4-amino-6-nitroquinazoline in DMF were added 56 mg (0.55 mmol) of potassium t-butoxide and 50 mg (0.50 mmol) of t-butylisocyanate, and then the reaction mixture was subjected to heating at 150° C. for 0.5 hour. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was purified by a silica gel chromatography to give 80 mg (yield: 36.0%) of the title compound.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue was purified by a silica gel chromatography