反应详情

150 mg (0.57 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline was dissolved in 10 ml of acetonitrile, and then 220 mg (1.14 mmol) of 2-piperidinocarbonylethylamine hydrochloride and 0.40 ml (2.85 mmol) of triethylamine were added thereto, followed by heating under reflux overnight. To the reaction solution was added water, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 191 mg (87.7%) of the title compound.

1. temperatureby heating
2. temperatureunder reflux overnight
3. extractionfollowed by extraction with ethyl acetate
4. washwashing with brine
5. dry with materialdrying over anhydrous sodium sulfate
6. distillationAfter the solvent was distilled off
7. customthe residue was purified by a silica gel column