Water → 4-Benzylamino-2-chloro-7-methylthieno[3,2-d]pyrimidine

HRID 1250619Notes

Reaction equation

HRID 1250619 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH:9]=[C:8]([CH3:11])[C:6]=2[N:7]=1.[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.O>CN(C=O)C>[CH2:13]([NH:20][C:4]1[C:5]2[S:10][CH:9]=[C:8]([CH3:11])[C:6]=2[N:7]=[C:2]([Cl:1])[N:3]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7504BenzylamineHCID 71470642,4-Dichloro-7-methylthieno(3,2-d)pyrimidine

Product 1

HCID 183264544-Benzylamino-2-chloro-7-methylthieno[3,2-d]pyrimidineYield 94.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 3 ml of DMF was dissolved 300 mg (1.4 mmol) of 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine, and after 220 mg (2.1 mmol) of benzylamine was added to the resulting solution, the mixture was stirred for 3 hours. Water was added to the reaction mixture, and crystals thus precipitated were filtered to give 375 mg (yield: 94.5%) of the title compound.

Workup

  1. customthus precipitated
  2. filtrationwere filtered

Sources & evidence

ORD record
ord-2e3745059a8e48919a045e098171b6f7
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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