Water → 2-Chloro-4-cyclohexylamino-7-methylthieno[3,2-d]pyrimidine

HRID 1250620Notes

Reaction equation

HRID 1250620 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH:9]=[C:8]([CH3:11])[C:6]=2[N:7]=1.[CH:13]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.O>CN(C=O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:19][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:5]2[S:10][CH:9]=[C:8]([CH3:11])[C:6]=2[N:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7965CyclohexylamineHCID 71470642,4-Dichloro-7-methylthieno(3,2-d)pyrimidine

Product 1

HCID 118220702-Chloro-4-cyclohexylamino-7-methylthieno[3,2-d]pyrimidineYield 98.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 3 ml of DMF was dissolved 300 mg (1.4 mmol) of 2,4-dichloro-7-methylthieno [3,2-d]pyrimidine, and after 204 mg (2.1 mmol) of cyclohexylamine was added to the resulting solution, the mixture was stirred for 3 hours. Water was added to the reaction mixture, and crystals thus precipitated were filtered to give 379 mg (yield: 98.2%) of the title compound.

Workup

  1. customthus precipitated
  2. filtrationwere filtered

Sources & evidence

ORD record
ord-35ab775f474f482681e449638b29920f
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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