HCID 20718796, compound → (+)-(R)-4-(3,4-Difluorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic Acid

HRID 1250706Notes

Reaction equation

HRID 1250706 reaction equation
C[O:2][C:3]([C:5]1[CH:6]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[C:17]([F:22])[CH:16]=2)[N:7]=[C:8]([O:13]C)[N:9]([CH3:12])[C:10]=1[CH3:11])=[O:4]>C(OCC)C>[F:22][C:17]1[CH:16]=[C:15]([C@@H:6]2[C:5]([C:3]([OH:4])=[O:2])=[C:10]([CH3:11])[N:9]([CH3:12])[C:8](=[O:13])[NH:7]2)[CH:20]=[CH:19][C:18]=1[F:21]

Participants

3

Reactant 1

HCID 20718796HCID 20718796, compound

Product 1

HCID 10660516(+)-(R)-4-(3,4-Difluorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic Acid

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4-(3,4-Difluorophenyl)-2-methoxy-1,6-dimethyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester was converted to (+)-4-(3,4-difluorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrinidine-5-carboxylic acid following steps C and D above in Example 14 to give the product as a crystalline solid from diethyl ether ([αD]=+48°, c=0.145 MeOH).

Sources & evidence

ORD record
ord-46b01e97f7ad41b1b2af23cf76c53a88
Source dataset
uspto-grants-2002_01
Patent number
US06339090B1

Reaction notes

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