HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 20718796, compound → (+)-(R)-4-(3,4-Difluorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 20718796 | HCID 20718796 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (+)-(R)-4-(3,4-Difluorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic Acid | HCID 10660516 | — |
Reaction Steps
4-(3,4-Difluorophenyl)-2-methoxy-1,6-dimethyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester was converted to (+)-4-(3,4-difluorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrinidine-5-carboxylic acid following steps C and D above in Example 14 to give the product as a crystalline solid from diethyl ether ([αD]=+48°, c=0.145 MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06339090B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-46b01e97f7ad41b1b2af23cf76c53a88 |
| Source note | uspto-grants-2002_01 |