反应详情

Triethylamine (1.06 ml) and tetradecyl isocyanate (1.64 g) were added to a solution containing 3-(2-hydroxyphenyl)-1-(4-methylpiperazino)-1-propanone (1.70 g) obtained in Example 3(4) in methylene chloride (17 ml). After being stirred for 18.5 hours at room temperature, the reaction mixture was diluted with chloroform, washed with saturated sodium hydrogencarbonate aqueous solution and brine successively, dried over sodium sulfate anhydride, and concentrated. The residue was purified by silica gel column chromatography (silica gel 100 g, chloroform:methanol=60:1 to 30:1), thereby yielding the entitled compound (3.04 g) as white solid.

1. washwashed with saturated sodium hydrogencarbonate aqueous solution and brine successively
2. dry with materialdried over sodium sulfate anhydride
3. concentrationconcentrated
4. customThe residue was purified by silica gel column chromatography (silica gel 100 g, chloroform:methanol=60:1 to 30:1)