2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate → 2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate Hydrochloride

Participants

Reaction Steps

4N Hydrochloric acid/ethyl acetate solution (1.48 ml) was added to a solution containing 2-[3-(4-methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate (2.40 g) in ethyl acetate (24 ml) while being cooled with ice. After being stirred for 45 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (2.22 g) as white solid.

Provenance & Evidence