2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate → 2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate Hydrochloride

HRID 1250774Notes

Reaction equation

HRID 1250774 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:22][C:23](=[O:42])[O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][CH2:32][C:33]([N:35]1[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]1)=[O:34])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:22][C:23](=[O:42])[O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][CH2:32][C:33]([N:35]1[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]1)=[O:34])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 99571202-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 185202772-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate Hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.48 ml) was added to a solution containing 2-[3-(4-methylpiperazino)-3-oxopropyl]phenyl N-tetradecylcarbamate (2.40 g) in ethyl acetate (24 ml) while being cooled with ice. After being stirred for 45 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (2.22 g) as white solid.

Workup

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-9bd807c484d04a798876099af7bd59da
Source dataset
uspto-grants-2002_01
Patent number
US06339154B1

Reaction notes

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