4-Fluorophenylboronic acid → HCID 18325035, compound

HRID 1250909Notes

Reaction equation

HRID 1250909 reaction equation
I[C:2]1[C:7](=[O:8])[C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[O:4][C:3]=1[C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=O)=O)=[CH:15][CH:14]=1.[F:23][C:24]([F:35])([F:34])[C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1.FC1C=CC(B(O)O)=CC=1>>[CH3:22][S:19][C:16]1[CH:17]=[CH:18][C:13]([C:3]2[O:4][C:5]3[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=3[C:7](=[O:8])[C:2]=2[C:28]2[CH:29]=[CH:30][C:25]([C:24]([F:35])([F:34])[F:23])=[CH:26][CH:27]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 2856454-Fluorophenylboronic acidHCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 18324985HCID 18324985, compound

Product 1

HCID 18325035HCID 18325035, compound

Procedure

Following the procedure of Example 1, Step 5, but substituting 3-bromo-2-(4-(methylthio)phenyl)-4H-1-benzopyran-4-one(0.1 g, 0.32 mmol) for 3-iodo-2-(4-(methylsulfonyl)phenyl)-4H-1-benzopyran-4-one and 4-trifluoromethylbenzeneboronic acid(0.066 g, 0.35 mmol) for 4-fluorobenzeneboronic acid, the title compound was obtained as a solid(0.05 g, 40%).

Sources & evidence

ORD record
ord-da85734d8aaa4ccfa4642b715a10987d
Source dataset
uspto-grants-2002_01
Patent number
US06340694B1

Reaction notes

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