1-Bromo-2-butyne → HCID 11337003, compound

HRID 1250919Notes

Reaction equation

HRID 1250919 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([S:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH3:2].Br[CH2:22][C:23]#[C:24][CH3:25]>>[CH2:1]([O:3][C:4](=[O:20])[CH:5]([S:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:22][C:23]#[C:24][CH3:25])=[CH:17][CH:18]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH3:2]

Participants

3

Reactant 2

HCID 27568621-Bromo-2-butyneHCID 11150633HCID 11150633, compound

Product 1

HCID 11337003HCID 11337003, compound

Procedure

2-(4-But-2-ynyloxy-phenylsulfanyl)-octanoic acid ethyl ester was prepared according to the general method as outlined in Example 1 (Step 2). Starting from 2-(4-hydroxy-phenylsulfanyl)-octanoic acid ethyl ester 13.6 g, 46 mmol) and 1-bromo-2-butyne(6.23 g, 47mmol). Yield 13.78 g (86%); amber oil; MS: 349.0 (M+H)+

Sources & evidence

ORD record
ord-05c0b84e026b4e4ab8707dfee4704418
Source dataset
uspto-grants-2002_01
Patent number
US06340691B1

Reaction notes

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