2-Butyn-1-ol → HCID 86757738, compound

HRID 1250937Notes

Reaction equation

HRID 1250937 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[S:22][CH:23]=[CH:24][CH:25]=3)=[CH:17][CH:16]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[CH2:26](O)[C:27]#[C:28][CH3:29]>>[CH2:26]([O:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][CH:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[S:22][CH:23]=[CH:24][CH:25]=3)=[CH:17][CH:16]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:7]=1)[C:27]#[C:28][CH3:29]

Participants

3

Reactant 2

HCID 129912-Butyn-1-olHCID 86757739HCID 86757739, compound

Product 1

HCID 86757738HCID 86757738, compoundYield 74%

Procedure

Ethyl {[4-(2-butynyloxy)phenyl]sulfanyl}[4-(2-thienyl)phenyl]acetate was prepared according to the general method as outlined in example 83 (step 2), starting from ethyl [(4-hydroxyphenyl)sulfanyl][4-(2-thienyl)phenyl]acetate (1.6 g, 4.3 mmol) and 2-butyn-1-ol (0.33 ml, 4.32 mmol); 1.34 g yellow oil. Yield 74%; MS(EI): 421.71 (M+H)+

Sources & evidence

ORD record
ord-37acf32e086b404fb79f2ee3d970e526
Source dataset
uspto-grants-2002_01
Patent number
US06340691B1

Reaction notes

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