HCID 18325115, compound → HCID 18325136, compound

HRID 1250947Notes

Reaction equation

HRID 1250947 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[N:11]=[C:10]([CH2:20][OH:21])[C:9]=2[CH2:22][CH2:23][OH:24])=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[N:11]=[C:10]3[C:20](=[O:21])[O:24][CH2:23][CH2:22][C:9]=23)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 18325115HCID 18325115, compound

Product 1

HCID 18325136HCID 18325136, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

To a solution of a crude crystal (1.0 g) of 2-[4-(4-fluorophenyl)-2-hydroxymethyl-6-methoxyquinolin-3-yl]-1-ethanol in chloroform (100 ml), manganese dioxide (10 g) was added, followed by stirring at room temperature for 2 hours. After the manganese dioxide was filtered off, the reaction mixture was concentrated under reduced pressure; the residue obtained was recrystallized from THF to yield the title compound (335 mg).

Workup

  1. filtrationAfter the manganese dioxide was filtered off
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customthe residue obtained
  4. customwas recrystallized from THF

Sources & evidence

ORD record
ord-db900c6a096c467c95b0f095d5eebcc6
Source dataset
uspto-grants-2002_01
Patent number
US06340704B1

Reaction notes

Loading…