Phosphorodichloridous acid, methyl ester → Chloro(methoxy)pyrrolidinophosphine

HRID 1250977Notes

Reaction equation

HRID 1250977 reaction equation
[CH3:1][O:2][P:3]([Cl:5])Cl.C[Si](C)(C)[N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1>C(Cl)Cl>[Cl:5][P:3]([O:2][CH3:1])[N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 76768Phosphorodichloridous acid, methyl esterHCID 847911-(Trimethylsilyl)pyrrolidine

Product 1

HCID 23414106Chloro(methoxy)pyrrolidinophosphineYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of methyldichlorophosphite (10.0 g, 75.24 mmol, 7.1 mL) in CH2Cl2 (50 mL) was added dropwise 1-(trimethylsilyl)pyrrolidine (13.1 mL, 10.8 g, 75.2 mmol) at 0° C. The resulting mixture was stirred for 2 h at room temperature. The solvent was removed under reduced pressure to give a colorless oil (11.97 g, 95%) as a product. 31P NMR (CDCl3) δ 182.3.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-f66d51982c204346b6aea9dd4e0291c2
Source dataset
uspto-grants-2002_01
Patent number
US06340749B1

Reaction notes

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