Sodium Hydroxide → HCID 9856593, compound

HRID 1251008Notes

Reaction equation

HRID 1251008 reaction equation
[CH3:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5][C:4]=2[C:3]=1[C:17]([O:19]C)=[O:18].[OH-].[Na+]>C1COCC1>[CH3:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5][C:4]=2[C:3]=1[C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10588717HCID 10588717, compound

Product 1

HCID 9856593HCID 9856593, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of 6-methyl-7-nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-carboxylic acid, methyl ester (0.80 g, 2.87 mmol) in THF (50 mL) was added aqueous 1.0N NaOH (4.3 mL, 4.3 mmol), and the reaction mixture was refluxed for 23 hours. The product is precipitated upon acidification with conc. HCL and recrystallized from water to give 0.73 g (96%).

Workup

  1. temperaturethe reaction mixture was refluxed for 23 hours
  2. customThe product is precipitated upon acidification with conc. HCL
  3. customrecrystallized from water
  4. customto give 0.73 g (96%)

Sources & evidence

ORD record
ord-54e8e249a5524c0ca6c8a7aa9db7991b
Source dataset
uspto-grants-2002_01
Patent number
US06340758B1

Reaction notes

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