反应详情

温度

100 °C

6-(4-Bromophenyl)-5H-thieno[3,2-c]pyridin-4-one (4.87 g) was added to phosphorus oxychloride (30 ml), and the resulting mixture was heated at 100° C. for 3 hr. The reaction solution was evaporated, and to the resulting residue were added ethyl acetate and water. The organic layer was washed with water, an aqueous solution of saturated sodium bicarbonate and brine, and dried over magnesium sulfate. The solvent was evaporated, to give 4-chloro-6-(4-bromophenyl)thieno[3,2-c]pyridine.

1. customThe reaction solution was evaporated
2. additionto the resulting residue were added ethyl acetate and water
3. washThe organic layer was washed with water
4. dry with materialan aqueous solution of saturated sodium bicarbonate and brine, and dried over magnesium sulfate
5. customThe solvent was evaporated