反应详情

4-(4-Ethylpiperazin-1-yl)-6-(4-methoxyphenyl)thieno[3,2-c]pyridine (5.2 g) was dissolved in 48% hydrobromic acid (50 ml), and the mixture was reacted at 130° C. for 1.5 hr. The reaction solution was evaporated, basified with potassium carbonate and extracted with chloroform. The chloroform layer was washed with water, dried and evaporated. The resulting residue was purified by NH-silica gel column chromatography (ethyl acetate), to give the title compound as a pale brown powder (4.0 g, yield; 80%).

1. customthe mixture was reacted at 130° C. for 1.5 hr
2. customThe reaction solution was evaporated
3. extractionextracted with chloroform
4. washThe chloroform layer was washed with water
5. customdried
6. customevaporated
7. customThe resulting residue was purified by NH-silica gel column chromatography (ethyl acetate)