Chloroacetyl chloride → 1-(2-Methoxyphenyl)piperazine

HRID 1251320Notes

Reaction equation

HRID 1251320 reaction equation
NCC[N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])[CH2:6][CH2:5]1.ClCC(Cl)=O>>[CH3:17][O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[N:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 103991861-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazine

Product 1

HCID 13461-(2-Methoxyphenyl)piperazineYield 50.8%

Procedure

Following the procedures in the Step 3 of EXAMPLE 1, the reaction of 4-[(2-amino) ethyl]-1-(2-methoxyphenyl)piperazine (4.19 mmol) and chloroacetyl chloride (4.68 mmol) gave 4-[2-(α-bromo)acetamido)ethyl]-1-(2-methoxyphenyl)piperazine (409 mg, 31%)

Sources & evidence

ORD record
ord-73b529b36aae43fca1aea51e597dcee9
Source dataset
uspto-grants-2002_01
Patent number
US06342498B1

Reaction notes

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