HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 1-(2-Methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 1-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazine | HCID 10399186 | — |
| Product | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | 50.8% |
Reaction Steps
Following the procedures in the Step 3 of EXAMPLE 1, the reaction of 4-[(2-amino) ethyl]-1-(2-methoxyphenyl)piperazine (4.19 mmol) and chloroacetyl chloride (4.68 mmol) gave 4-[2-(α-bromo)acetamido)ethyl]-1-(2-methoxyphenyl)piperazine (409 mg, 31%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342498B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-73b529b36aae43fca1aea51e597dcee9 |
| Source note | uspto-grants-2002_01 |