Triethylamine → HCID 18323648, compound

HRID 1251324Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]Br)[CH2:11][CH2:10]1.[F:23][C:24]1[CH:32]=[C:31]2[C:27]([C:28]([C:33]3[CH2:34][CH2:35][NH:36][CH2:37][CH:38]=3)=[CH:29][NH:30]2)=[CH:26][CH:25]=1.C(N(CC)CC)C>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:36]2[CH2:37][CH:38]=[C:33]([C:28]3[C:27]4[C:31](=[CH:32][C:24]([F:23])=[CH:25][CH:26]=4)[NH:30][CH:29]=3)[CH2:34][CH2:35]2)[CH2:11][CH2:10]1

Participants

Reactant 3

HCID 8471Triethylamine

HCID 110530726-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

HCID 18323651HCID 18323651, compound

Product 1

HCID 18323648HCID 18323648, compoundYield 65.2%

Procedure

Following the same procedure reported in the Step 2 of EXAMPLE 13, the reaction of 1-(2-methoxyphenyl)-4-(6-bromohexanoyl)piperazine (2.37 mmol) with 6-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (2.37 mmol) and triethylamine (2.87 mmol) gave the alkylation product (780 mg, 65%).

Sources & evidence

ORD record: ord-56438a5f24e34b25a559e2c1e17ff186
Source dataset: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06342498B1

Reaction notes

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