HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 4-(piperidin-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 4-(piperidin-1-yl)benzoate | HCID 13813852 | — |
Reaction Steps
Reaction of ethyl 4-fluorobenzoate with piperidine (3 equivalents) in acetonitrile may be carried out at reflux for 4 days. Dilution of the cooled reaction mixture with several volumes of water provides a precipitate, which may be filtered to provide ethyl 4-(piperidin-1-yl)benzoate. Reduction of the ester with lithium aluminum hydride (2 equivalents) in tetrahydrofuran provides the corresponding alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342497B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-6cb6799b4a764d3fac9df5a1d191f153 |
| Source note | uspto-grants-2002_01 |