反应详情

Reaction of ethyl 4-fluorobenzoate with piperidine (3 equivalents) in acetonitrile may be carried out at reflux for 4 days. Dilution of the cooled reaction mixture with several volumes of water provides a precipitate, which may be filtered to provide ethyl 4-(piperidin-1-yl)benzoate. Reduction of the ester with lithium aluminum hydride (2 equivalents) in tetrahydrofuran provides the corresponding alcohol.

1. temperatureat reflux for 4 days
2. customprovides a precipitate, which
3. filtrationmay be filtered