Trifluoroacetic acid → HCID 22943378, compound

HRID 1251350Notes

Reaction equation

HRID 1251350 reaction equation
[CH2:1]([O:4][C:5]([NH:7][C:8]1[C:9](=[O:20])[N:10]([CH2:14][C:15]([O:17]CC)=[O:16])[CH:11]=[CH:12][CH:13]=1)=[O:6])[CH:2]=[CH2:3].FC(F)(F)C(O)=O>ClCCl.C1(C)C=CC=CC=1>[CH2:1]([O:4][C:5]([NH:7][C:8]1[C:9](=[O:20])[N:10]([CH2:14][C:15]([OH:17])=[O:16])[CH:11]=[CH:12][CH:13]=1)=[O:6])[CH:2]=[CH2:3]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57242741HCID 57242741, compound

Product 1

HCID 22943378HCID 22943378, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

The compound of example 60 (1.00 g) is treated with 50% trifluoroacetic acid in dichloromethane (10 mL) for 1 hour at 0° C., and 3 hours at room temperature. The solution is diluted with toluene (50 mL) and the solvent is removed in vacuo to afford the title compound.

Workup

  1. custom3 hours
  2. customat room temperature
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-7655957f11ab40e3b334389736fe6515
Source dataset
uspto-grants-2002_01
Patent number
US06342504B1

Reaction notes

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