反应详情

To a solution of 5-(4-nitrophenyl)pyrazole (10.1 g) in ethanol (100 ml) was added Tin(II) chloride dihydrate (35.7 g) and concentrated hydrochloric acid (25.5 ml). After the addition was completed, the reaction mixture was refluxed for 3 hours. After cooling, the solvent was evaporated and strongly basified (NaOH solution) and then extracted with chloroform. The extract was washed with brine, dried (MgSO4) and evaporated to dryness to obtain the title compound (8.1 g).

1. additionAfter the addition
2. temperaturethe reaction mixture was refluxed for 3 hours
3. temperatureAfter cooling
4. customthe solvent was evaporated
5. extractionstrongly basified (NaOH solution) and then extracted with chloroform
6. washThe extract was washed with brine
7. dry with materialdried (MgSO4)
8. customevaporated to dryness